T cells and IL-17 in lupus nephritis
نویسندگان
چکیده
منابع مشابه
Cytokines (IL-17, IL-23, and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago.
Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SS...
متن کاملT cells and B cells in lupus nephritis.
T and B lymphocytes play diverse roles at multiple stages in the development and progression of lupus nephritis. Disruption of T- and B-cell regulatory functions by environmental and genetic influences permits pathogenic effectors to emerge in disease. New insights into the biology of these multifunctional cells offer novel targets for intervention in lupus nephritis and systemic autoimmunity.
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T cells that express IL-17 infiltrate the kidneys of patients with systemic lupus erythematosus. A significant proportion of these cells are CD3(+)CD4(-)CD8(-) double-negative T cells. In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 receptor in lymphocytes from the...
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The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from developm...
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IL-17 producers in T cell subsets have been recently identified to play protective roles against bacterial infection by inducing neutrophil infiltrations, organizing granulomas and acquired immunity. During ontogeny, T cells develop, maturate and localize at different tissues depending on V repertoires. V 1+, V 4+ and V 6+ cells are reportedly able to produce IL-17. V 6+ cells, which develop in...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2017
ISSN: 1521-6616
DOI: 10.1016/j.clim.2016.04.010